In the initial stage of atherosclerosis, oxLDL activates endothelial cells by inducing the expression of several cell surface adhesion molecules including ICAM-1 and VCAM-1 which recruit circulating monocytes from the blood into intima, where monocytes differentiate into macrophages and become foam cells by internalizing modified lipoproteins [2,3]. The gene discussed is VCAM1; the disease is atherosclerosis.