Herpes simplex virus type 1 (HSV-1) capsid protein VP26 was identified to bind to the host factor de novo DNA methyltransferase DNMT3A during infection, and downregulating DNMT3A with siRNA or suppression by the human DNMT inhibitor RG108 can dramatically trigger a decrease in HSV-1 titres [19]. Here, DNMT3A is linked to infection.