A mechanism that elicits the onset of depression and at the same time chronic inflammation in patients with psoriasis is the hyperactivity of the HPA axis, resulting in the release of increased levels of CRH, ACTH, and cortisol and in a stimulation of the transcription factor NF-kB and of the proinflammatory cytokines in the skin [152]. Here, NFKB1 is linked to psoriasis.