The most relevant upstream regulators of mTORC1 suffering genetic alterations in the context of CRC are: PIK3CA gene-gain-of-function mutations [94,95], PTEN gene-inactivating mutations [95], or the STK11/LKB1 gene [96], which encodes for an mTORC1 repressor. The gene discussed is PIK3CA; the disease is colorectal carcinoma.