Flavonoids such as catechin, cyanidin, luteolin, epicatechin, quercetin, and kaempferol exert anticancer properties on various cancer cell lines through several mechanisms, such as inhibiting the phosphorylation of epidermal growth factor receptor (EGFR), increasing DNA fragmentation, suppressing signal transduction enzymes, and counteracting angiogenesis. The gene discussed is EGFR; the disease is cancer.