KDR and neoplasm: Murine breast cancer WA4 cell line inhibited with induction of cell cycle arrest at the G0/G1 phase and apoptosis through caspase-3 activation, reduced cell proliferation and induced apoptosis in MCF-7 cells, antiangiogenic potential (significantly inhibited tumour growth and VEGF receptor 2 (VEGFR-2) phosphorylation), produced synergistic cytotoxic effects