For example, Parkinson’s disease (PD) is characterized by the presence of α-synuclein (α-syn) deposits, Alzheimer’s disease (AD) is characterized by the presence of amyloid-beta (Aβ) and tau plaques, and type-2 diabetes (T2D), apart from insulin resistance, is also characterized by the presence of human islet amyloid polypeptide (hIAPP) amyloid fibrils [4]. The gene discussed is MAPT; the disease is Alzheimer disease.