In particular, in vivo investigations via intratumoral injection in H22 xenograft Kunming mice [90] demonstrated that GA-CUR-Lip, compared to free CUR, also exhibited a much better capability to inhibit tumor growth, inducing apoptosis of tumor tissue, reducing VEGF expression, and upregulating caspase-3 in tumor tissues. This evidence concerns the gene CASP3 and neoplasm.