The antiangiogenic and antimetastatic effect of GA in HCC could be related to downregulation of the expression of vascular endothelial growth factor (VEGF), lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) (a marker for lymphatic metastasis), and matrix metalloproteinase-2 (MMP-2) protein (Figure 1). This evidence concerns the gene MMP2 and hepatocellular carcinoma.