AKT1 and hepatocellular carcinoma: Since HCC is associated with the activation of the PI3K/Akt/mTOR signaling pathway, facilitating the development of tumor cell proliferation, angiogenesis, metastasis, and invasion, Wang and coworkers [74] tested a nanosystem self-assembled from a PEI-GA amphiphilic copolymer as a versatile gene/drug dual delivery nanoplatform using DOX and a short hairpin RNA silencing Akt1 (shAkt1).