Although both alterations in TLR signalling [95] and the ECS [96] have been associated with QOL indices such as mental health in select populations, such as patients with major depressive disorder and trauma-injury survivors, respectively, we determined no significant correlation between the expression of TLR3/4, or components of the ECS, and the QOL readings made in this study cohort of pwMS (data not shown). The gene discussed is TLR3; the disease is major depressive disorder.