Given the inhibitory effects of THC:CBD on TLR3 signalling to CXCL10 and IFN-β in PBMCs, in addition to evidence linking TLR4 to MS pathogenesis [15,16], we next set out to determine the proclivity of THC and CBD, when delivered alone and in a 1:1 combination, to modulate TLR4-induced TNF-α protein expression in PBMCs isolated from HCs and pwMS. The gene discussed is TLR4; the disease is myeloid sarcoma.