The immunogenicity (including anti-diphtheria, anti-tetanus, anti-hepatitis B, anti-pertussis (PT), anti-filamentous hemagglutinin (FHA), anti-pertactin (PRN), anti-polyribosyl ribitol phosphate (PRP), polio serotype 1, polio serotype 2, and polio serotype 3) values of different types of combined vaccines are shown in Table 2 and Supplementary Figures. The gene discussed is CIAO3; the disease is diphtheria.