Similarly, fecal biomarkers derived from eosinophils, such as eosinophil derived neurotoxin (EDN) and eosinophilic cationic protein (ECP), have been evaluated as possible biomarkers of non-IgE mediated food allergy but very limited data support their role in populations with gastrointestinal disorders [106,134,135]. This evidence concerns the gene RNASE3 and digestive system disorder.