Moreover, β-carotene, which is the main carotenoid found on the fruit peel extract, used for the miso-type sauce enhancement, has been reported for its beneficial role in regulating the eNOS expression and molecules adhesion via the activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) pathway in an in vitro model of endothelial dysfunction induced by IL-1β [32]. The gene discussed is IL1B; the disease is endothelial dysfunction.