Some studies have shown that PKU patients have a higher vascular risk compared to healthy controls [10], with a higher BMI, a higher prevalence of hypertension, higher levels of total and non-HDL cholesterol, lower levels of HDL cholesterol, greater carotid stiffness, a worse inflammatory profile, and higher plasma levels of C-reactive protein and amyloid A protein as well as markers of oxidative stress [11]. This evidence concerns the gene CRP and Hypertension.