Additionally, in case of clinical suspicion of hypercortisolism, male hypogonadism, fertility disturbances or hypopituitarism, a more detailed hormonal evaluation may be performed, which includes cortisol level measurement, 1 mg overnight dexamethasone suppression test, total testosterone, sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH), luteinizing hormone (LH), androstenedione, estradiol, 17-OH-progesterone, prolactin, and insulin-like growth factor 1 (IGF-1) [2]. The gene discussed is SHBG; the disease is adrenal gland hyperfunction.