On the contrary, the downregulation of the lysosome pathway can increase the risk of developing neurodegenerative diseases, as described in the study by Hara et al. [49], where Atg5 (autophagy-related 5) gene-deficient mice developed progressive deficits in motor function, mirrored by deposition of cytoplasmic inclusion bodies and aggregates in neurons. Here, ATG5 is linked to neurodegenerative disease.