Further, a potential energy mechanism for the association between the loss of Clostridia abundance and diversity and obesity and metabolic syndrome comes from T-Myd88-knockout mice [71], increases in Clostridia colonization were associated with a leaner phenotype and down-regulation of CD36, an enterocyte receptor involved in lipid absorption, suggesting decreased energy absorption from the gut. The gene discussed is CD36; the disease is metabolic syndrome.