HCRT and Hypoglycemia: In our previous study, we demonstrated that intravenous 2-deoxy-d-glucose (2DG) administration-induced reduction in glucose availability (glucoprivation) and subcutaneous insulin-induced hypoglycemia stimulated feeding behavior and activated orexin A neurons and neurons in the lateral hypothalamic/perifornical area (LH/PAF) and neurons in the dorsomedial part of the Arc, probably neuropeptide Y (NPY) neurons, but did not activate MCH neurons [23].