As it is reported that the amounts of synapsin-2 are higher in the hippocampus of older rats than in younger ones, that the amounts of tubulin alpha are lower in the hippocampus of old rats than young ones [22] and that dynamin is needed for memory formation [23], the opposite amounts of these proteins in the hippocampus in mice administered matcha and decaffeinated matcha indicated that the administered samples have the ability to ameliorate aging and cognitive impairment, presumably by increasing nerve cell plasticity. This evidence concerns the gene SYN2 and Cognitive impairment.