PTGS1 and early-onset autosomal dominant Alzheimer disease: Acacia pennata had various biological activities such as anti-nociception against pain [48], anti-inflammation through inhibition of cyclooxygenases-1 and -2 enzyme activities due to the flavonoid compositions [49], anti-cancer of pancreas and prostate [50], prevention of liver damage after acetaminophen-induced genotoxicity [51], and anti-Alzheimer disease by prevention of β-amyloid aggregation [52].