Furthermore, the bioinformatic data obtained from the gene dataset concerning the evaluation of the FZD7 gene in tissues of patients with moderate (grade 2) and severe (grade 3) NAFLD downloaded from Gene Expression Omnibus database corroborated that the FZD7 mRNA expression in patients was found to be significantly upregulated according their steatosis grade when compared to healthy controls, thus confirming the usefulness of the protein FZD7 contained in the exosomes in the follow-up of the disease. This evidence concerns the gene FZD7 and metabolic dysfunction-associated steatotic liver disease.