FZD7 and metabolic dysfunction-associated steatotic liver disease: In the light of this evidence, the aim of this study was to evaluate the modulation of the FZD7 expression levels in plasma-derived exosomes of NAFLD-affected patients, before and after specific lifestyle interventions, as well as to estimate the effectiveness of the specific interventions on downregulation of the protein, in order to investigate on the potential use of the FZD7 as novel diagnostic and prognostic biomarker of NAFLD.