PTEN and bladder transitional cell carcinoma: Moreover, the treatment of urinary bladder urothelial carcinoma cells (T24 and J82 cell lines) with pomegranate extract increased the expression of profilin 1 to increase the expression of the PTEN (phosphatase and tensin homolog) gene, which, in turn, may inhibit the Akt/mTORC1 (phosphoinositide 3-kinase/mammalian target of rapamycin complex 1) signaling pathway to prevent the proliferation/migration of urothelial BC cells.