A retrospective study that analyzed 82 female RA patients treated with TNF-α inhibitors for 12 weeks demonstrated that high NLR and PLR subgroups at baseline showed an increased rate of EULAR non-response compared to low NLR and PLR subgroups (p = 0.01 and p = 0.047, respectively) and that these were significantly associated with an increased risk of EULAR non-response [13]. The gene discussed is TNF; the disease is rheumatoid arthritis.