APOE and cardiac hypertrophy: At the expression level, RSV was previously reported to induce HO-1 expression in vitro in neuro-2A cells exposed to lipopolysaccharide [55], cultured HL-1 cell line of atrium-derived myocytes [56], in aortic tissue of AngII-ApoE-/- murine animal model [57], umbilical vein endothelial cells [58] and myocardial hypertrophy in rats [59].