Induction of DN was confirmed by a significant increase in serum levels of urea and creatinine, as well as serum cations, Na+ and K+, in addition to the urinary albumin-to-creatinine ratio, with a significant decrease in serum albumin as well as urinary Na+ and K+, as compared to non-diabetic control (Table 2). The gene discussed is ALB; the disease is liver dysplastic nodule.