The primary aim of this study was to evaluate biomarkers of iron turnover, sTfR, and hepcidin-25 in patients at various stages of MM progression, and examine their relationship with indicators of anemia and iron status (hemoglobin, red blood cell indices, ferritin, and serum iron concentration) and renal impairment (serum creatinine, estimated glomerular filtration rate–eGFR, and urinary NGAL). This evidence concerns the gene HAMP and anemia (phenotype).