LCN2 and Miyoshi myopathy: In theory, a validated biomarker can act as a surrogate of underlying disease pathways and inform the physician on the alterations in organ-specific processes; for example, our previous studies demonstrated that urinary insulin growth factor binding protein 7 (IGFBP-7), neutrophil gelatinase-associated lipocalin (NGAL) monomer, and transgelin-2 may be markers of renal impairment in patients with MM [3,4].