TNF and Sepsis: Aside from this, since the drastic surge of sepsis due to global outbreaks of severe acute respiratory failure syndrome-associated coronavirus 2 (SARS-CoV-2), consequently the demand or necessity has been increased for better surrogate prodiagnostic markers than the existent sepsis biomarkers such as myeloperoxidase (MPO), procalcitonin (PCT), and tumor necrosis factor-alpha (TNF-α), which is a soluble molecule, a so-called non-cellular (molecular) index [5].