In addition, other experimental studies revealed that adipocytes co-cultured with melanoma cells induce the secretion of chemoattractant factors (CXCL1, CXCL2, and CXCL5) added to a local immune cell recruitment, especially of M2 macrophages, in the “tumour niche” [236,245,246]. Here, CXCL2 is linked to neoplasm.