PROS1 and neoplasm: Besides this, the melanoma cells–adipocytes communication in tumour niche is expressed by an elevated expression of cyclin D1 and Cox-2 oncogenic proteins in tumour cells, along with cell regulatory proteins, such as inhibitor of apoptosis protein-2 (IAP-2), myeloid cell leukaemia 1 (Mcl-1), B-cell lymphoma 2 (Bcl-2), and B-cell lymphoma-extra large (Bcl-xL) [264].