Recent reports show a “bidirectional communication” between melanoma cells and adipocytes, especially in obese patients, consisting of the secretion of high amounts of pro-inflammatory factors such as IL-6, IL-11, TNF-α, monocyte chemoattractant protein (MCP)-1/CCL2, and PAI-1 by the excessive fat [238,239]. This evidence concerns the gene IL6 and melanoma.