Furthermore, microbiota may influence immunotherapy response and toxicity, as demonstrated by the intratumour administration of CpG oligodeoxynucleotides, which mimic bacterial DNA administrated in melanoma experimental mice models, in association with an antibody against IL-10 receptor, which increase TNF production and CD8 T cells stimulation, resulting in tumour growth inhibition [273]. The gene discussed is CD8A; the disease is neoplasm.