During melanoma progression, CAFs may represent an important amount within the tumour cells’ population, displaying variable functions such as immunosuppression, due to TGF-β activity, which include inhibition of migration, maturation, and antigen presentation by DCs, increase in Tregs number, and reduction in the expression of perforin, granzymes, Fas ligand, and IFN-γ in cytotoxic T cells [156]. The gene discussed is TGFB1; the disease is melanoma.