Recent data have demonstrated a correlation between keratinocytes and corticotropin-releasing hormone-proopiomelanocortin (CRH-POMC) axis in about 80% of melanomas, along with adrenocorticotropic hormone (ACTH) production in about 70% of melanomas, with α-melanocyte-stimulating hormone (α-MSH) release in over 50% of melanomas [170] and with the functional cell-specific MSH receptor or melanocortin 1 receptor (MC1R) [171]. This evidence concerns the gene CRH and melanoma.