It was demonstrated that human and mouse melanoma cells metastasis was inhibited in vitro by thymoquinone, a bioactive phytocompound, by decreasing the NLRP3 inflammasome expression, accompanied by a reduction in caspase-1 proteolytic cleavage, which led to IL-1β and IL-18 inhibition, as well as NF-κB activity suppression [116]. Here, IL18 is linked to melanoma.