NFKB1 and metastatic melanoma: Other works have demonstrated that ASC is an inhibitor of carcinogenesis by NF-κB transcriptional activity and IκB kinase α/β phosphorylation suppression in primary melanoma, while up-regulated ASC is stimulating the inflammasome, via IL-1β secretion and NF-κB activity, in metastatic melanoma [113,114].