Splicing factor 3b subunit 1 (SF3B1) represents the largest component of the spliceosome factor 3b (SF3B) complex, spliceosome mutations becoming the most fascinating pathway detected in human cancer, including acral and mucosal melanomas, haematological malignancies, and solid tumours, having also prognostic significance [74,75]. This evidence concerns the gene SF3B1 and mucosal melanoma.