Melanomas display immunostaining characteristics of melanocytic differentiation such as protein melan-A (MelanA) or MART1, microphtalmia-associated transcription factor (MITF), Human Melanoma Black (HMB45), SRY-related HMG-box 10 protein (SOX10), and S-100 protein positivity [24,25,52]. The gene discussed is MLANA; the disease is melanoma.