The genes that are associated with cases of familial melanoma are: cyclin-dependent kinase inhibitor 2A (CDKN2A), melanocortin-1 receptor (MC1R), MITF, cyclin-dependent kinase 4 (CDK4), protection of telomeres 1 (POT1), telomerase reverse transcriptase (TERT) promoter region (TERT), adrenocortical dysplasia protein homolog (ACD), telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP), and BRCA1 associated protein 1 (BAP1) [57]. Here, CDK4 is linked to familial melanoma.