Consequently, they release different cytokines, proteases, growth factors, biological amines, such as histamine, which reduces the antitumoural defence mechanisms, chemokines, neuropeptides, variable enzymes, and angiogenic factors, such as heparin, VEGF, TGF-β, and IL-8, the latter being demonstrated as a growth factor in different melanoma cell lines [160]. The gene discussed is VEGFA; the disease is melanoma.