INS and type 2 diabetes mellitus: Further, Obese normotensive ND and obese hypertensive with T2D patients had elevated serum leptin levels (p < 0.001, p < 0.001) and HOMA-IR (p = 0.01) when compared with normotensive ND controls, while no significant difference in serum total cholesterol (p = 0.60), LDL-cholesterol (p = 0.99), triglycerides (p = 0.08), and insulin (p = 0.15) was observed.