The urinary markers tissue metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7), which are recently discovered inducers of G1 cell-cycle arrest and are key stress biomarkers of AKI, are considered superior to known damage biomarkers such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) [21]. The gene discussed is TIMP2; the disease is acute kidney injury.