CD274 and infection: Combining MHC depletion with ectopic expression of immunoregulatory suppressive genes such as B7-H1/PD-L1, B7-H2, CTLA-4-Ig, HLA-E, and CD47 will enhance hypoimmunity (Deuse et al., 2019; Gornalusse et al., 2017; Han et al., 2019; Harding et al., 2019; Rong et al., 2014) but will broadly suppress alloreactive immunity, NK cells, and macrophages (Mogensen, 2009), thus significantly increasing the possible risk of uncontrolled infection of the graft cells.