PRKN and Parkinson disease: However, the Pink1 or Prkn KO mouse models are unable to recapitulate selective and overt neurodegeneration seen in PD (Kitada et al., 2007; Xiong et al., 2009; Gispert et al., 2009; Akundi et al., 2011) or validate the important in vitro findings for the function of PINK1/Parkin in mitophagy (Whitworth and Pallanck, 2017; Cummins and Gotz, 2018).