Since it has been indicated by the scRNA-seq data that endothelial cells of venous and tip cell origin are responsible for cavernoma formation [21], it will be interesting to investigate further regarding if and how the immune genes (Lbp, Cd55 and Vcam1) identified in this study that are associated with venous/venous capillary endothelial cells contribute to cavernoma formation. The gene discussed is LBP; the disease is cavernous hemangioma.