Recently, our group used single-cell RNA sequencing (RNA-seq) to study transcriptional diversity of endothelial cells in vascular cavernomas and showed that it is the endothelial cells of venous and tip cell origin that are responsible for the formation of cavernomas, while endothelial cells of arterial origin are resistant to the Ccm3 deletion [21]. Here, PDCD10 is linked to cavernous hemangioma.