Similar observations can be found in our previously published spatial transcriptomics data [21] (acute CCM model; P8 mouse brain cryosections of Ccm3iECKO mice and wild-type control) where the proportion of spots in the cerebellum that express Cxcl1, Ccl2, and Icam1 genes was much higher in the Ccm3iECKO mice than that of the wild-type mice (Fig. 2A). Here, ICAM1 is linked to cerebral cavernous malformation.