Next, we investigated the correlation between disease severity in chronic CCM, as determined by lesion size, and the levels of the eight up-regulated cytokines and chemokines: IL-1β, IL-6, TNF, CXCL1/KC/GRO, CXCL2/MIP-2, CCL2/MCP-1, CCL3/MIP-1α and CXCL10/IP-10. This evidence concerns the gene CALCA and glycogen storage disease VI.