The transcriptomic profiles of endothelial cells from mice with endothelial-specific deletion of the Ccm3 gene were analysed for both acute and chronic CCM, which showed up-regulation of CCM-associated immune genes that encode proinflammatory cytokines and chemokines, as well as endothelial adhesion molecules. The gene discussed is PDCD10; the disease is cerebral cavernous malformation.