Clusters of NETs (i.e., DAPI+MPO+CitH3+ +) can be seen for sporadic CCM in the proximity of the endothelium of cavernoma, but not for the healthy control (Supplemental Fig. 13A), similar to what was seen for the Ccm3iECKO mice (Fig. 7A, B). Here, MPO is linked to cerebral cavernous malformation.