Since the chemokine CXCL1 and the cytokine CCL2 have chemoattractant roles and ICAM1 induces leukocyte interactions, their high expression in the periphery of cavernomas suggested a role in leukocyte recruitment and leukocyte endothelial transmigration for the endothelial cells lining the cavernomas. This evidence concerns the gene ICAM1 and cavernous hemangioma.