With respect to the genes having interaction(s) with miRNAs, we realized four down-regulated vDEGs (TMEM100, MYH11, CHRDL1, and FAM107A) to the accompaniment of five up-regulated vDEGs (KLK10, CLDN1, SLC6A6, MMP11, and SLC7A5) being documented by the GEPIA in both COAD and READ cancer types. The gene discussed is TMEM100; the disease is cancer.