However, we had a chance of detecting three noticeably hyper-methylated/under-expressed genes (TCF21, MYH1, and DES) and seven outstandingly hypo-methylated/over-expressed genes (CCL20, CEMIP, CLDN1, KRT23, MMP7, SLC6A6, and SLC7A5) which not only were among v-DEGs-DMGs but also, pursuant to the GEPIA and the MEXPRESS they are of verified expressional and methylational value in both COAD and READ cancer types. The gene discussed is TCF21; the disease is reading.