However, we had a chance of detecting three noticeably hyper-methylated/under-expressed genes (TCF21, MYH1, and DES) and seven outstandingly hypo-methylated/over-expressed genes (CCL20, CEMIP, CLDN1, KRT23, MMP7, SLC6A6, and SLC7A5) which not only were among v-DEGs-DMGs but also, pursuant to the GEPIA and the MEXPRESS they are of verified expressional and methylational value in both COAD and READ cancer types. This evidence concerns the gene CLDN1 and cancer.