Interestingly, we found that ARHGs with active copy number increase (e.g. MYC, EIF4EBP1, EGFR) and ARHGs with active copy number loss (e.g. ATG16L1, MTOR, ULK1) also showed high expression in lung cancer tissues (Fig 1C). This evidence concerns the gene EIF4EBP1 and lung carcinoma.