LTBP4 and cardiomyopathy: Finally, mutations in exons 51 and 52, as well as latent transforming growth factor beta-binding protein 4 (LTBP4), have been shown to be significantly associated with improved or sustained cardiac health and function [Level 4];[21, 22, 35]; mutations in exons 12, 14, 15, 16, and 17 with increased risk of cardiomyopathy [Level 4] [35].