Hepatic manifestations included liver failure (36%, 9–69; [4, 177]), right hypochondriac tenderness (31%, 1–75; [4, 35]), hepatomegaly (29%, 3–64; [4, 56]), jaundice (26%, 16–36; [15, 393]), AST elevation (97%, 97–100; [3, 660]) and raised ALT (94%, 93–96; [2, 625]) and LDH (52%, 36–68; [3, 304]). This evidence concerns the gene GPT and liver failure.