Staphylococcus aureus α-haemolysin (Hla) can target epithelial cells through binding to disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Table 1) [46], whereas the β-toxin from C. perfringens specifically interacts with CD31 and platelet endothelial cell adhesion molecule-1 (PECAM-1) receptors (Table 1), allowing targeted infection of endothelial cells [47]. This evidence concerns the gene PECAM1 and infection.