FRS2 and neoplasm: Moreover, miR-200c regulates tumor progression by targeting several other proteins, such as metastasis associated lung denocarcinoma transcript 1 (MALAT1), hypoxia-inducible factor 1, alpha subunit (HIF-1a), homeodomain interacting protein kinase 1 (HIPK1)/β-catenin, checkpoint kinase 1 (CHK1) and fibroblast growth factor receptor substrate 2 (FRS2), which are also potential therapeutic targets for tumor treatments [10–13].