PAK2 and non-small cell lung carcinoma: Above all, this study demonstrated that circ_0008717 was stably packaged into exosomes in NSCLC, and functionally, circ_0008717 was an oncogenic factor that promoted tumorigenesis in NSCLC by elevating PAK2 expression through miR-1287-5p, which might offer a novel insight into the understanding of exosomal circRNA biology in NSCLC, and the development of exosome-based therapeutic strategy for NSCLC patients.