Therefore, a role for CNP to facilitate the expansion of adipose tissue and increase in thermogenic markers—coupled with previous observations identifying important functions of CNP in promoting angiogenesis and (endothelial) proliferation while reducing (cardiomyocyte) hypertrophy and fibrosis and preventing inflammation (7, 8, 11)—intimate that CNP drives the healthy expansion of WAT, preventing the complications of metabolic syndrome and obesity. The gene discussed is CNP; the disease is obesity due to melanocortin 4 receptor deficiency.