Seven days after viral infection, the hepatic LXRα, but not LXRβ, mRNA levels were reduced, showing that the expression of LXRα, along LXRα-dependent genes, was successfully blunted in Ad-ShLxrα injected animals compared to control animals injected with an adenovirus expressing a scrambled shRNA (Ad-ShSCR), highlighting the efficacy of LXRα targeting (fig. This evidence concerns the gene NR1H3 and viral infectious disease.