HMGB1 and Hypoglycemia: The global ablation of Hmgb1 generates a severe phenotype with perinatal mortality (33), likely due to a defective glucocorticoid signaling leading to a poor utilization of hepatic glycogen and resulting in a lethal hypoglycemia, whereas hepatocyte-specific HMGB1 ablation did not have a major impact under homeostatic conditions (34).