In fact, preoperatively, surfactant-specific protein SP-B is increased in all CHD, while MPO (neutrophil) activity is decreased only in tetralogy of Fallot, and albumin and surfactant-specific protein-A are increased only in ASD and ventricular septal defect, compared to age-matched controls [21]. The gene discussed is ALB; the disease is ventricular septal defect 1.