GALC and lysosomal storage disease: Krabbe disease (globoid cell leukodystrophy) is an autosomal recessive lysosomal storage disease caused by mutations in the gene encoding the hydrolytic enzyme galactosylceramidase (GALC).1 This enzyme is responsible for the degradation of galactosylceramide (GalCer; a type of ceramide) and galactosylsphingosine (psychosine).