Its mammalian paralogue ACF7/MACF1 was discovered as an actin–MT cross‐linker (Byers et al., 1995; Leung et al., 1999), later shown to be involved in neuronal development (Goryunov et al., 2010; Ka et al., 2014; Ka & Kim, 2015; Sánchez‐Soriano et al., 2009) and linked to lissencephaly (OMIM #618325). Here, MACF1 is linked to lissencephaly spectrum disorders.