Also, the decrease was appeared in total protein level of AKT and STAT5 but not ERK1/2 and STAT3 (Figure 5), Combining the results shown in Figure 1(a,b), we have demonstrated a potent inhibitory effect of SNS-032 on the proliferation of DLBCL cells. The gene discussed is AKT1; the disease is diffuse large B-cell lymphoma.