While a declined BCL-2 protein was absent in SU-DHL-2 (ABC-DLBCL) and slightly seen in SU-DHL-4 (GCB-DLBCL), but BCL-2 mRNA was significantly declined in both cell lines, owing to the different mechanisms of BCL-2 regulation between GCB and ABC DLBCL.36,37 The result further shown that SNS-032 induced cell cycle arrest in DLBCL cells was associated with decreased Cyclin D1, as well as increasing levels of P53 and P21. The gene discussed is CCND1; the disease is diffuse large B-cell lymphoma.