It has been noticed that the ABC-DLBCL subtype has the worst prognosis and the most insensitive to current treatment regimens among the three subtypes.7 In contrast with GCB-DLBCLs (76%) and PMBCLs (64%), the patients with ABC-DLBCLs (16%) are inclined to poorer 5-y survival rate.8 ABC-DLBCL is characterized by activated NF-κB,9,10 which, after released from IκBα, tends to translocate from cytoplasm into the nucleus. Here, NFKBIA is linked to aneurysmal bone cyst.