We investigated the toxic effect of SNS-032 on the R-CHOP sensitive GCB-DLBCL (SU-DHL-4, OCI-LY-1, and OCI-LY-19) and insensitive ABC-DLBCL (SU-DHL-2) cell lines, these four cells incubating with various concentrations of SNS-032 for 48 hours, followed by MTS assay. The gene discussed is DDIT3; the disease is diffuse large B-cell lymphoma.