While a declined BCL-2 protein was absent in SU-DHL-2 (ABC-DLBCL) and slightly seen in SU-DHL-4 (GCB-DLBCL), but BCL-2 mRNA was significantly declined in both cell lines, owing to the different mechanisms of BCL-2 regulation between GCB and ABC DLBCL.36,37 The result further shown that SNS-032 induced cell cycle arrest in DLBCL cells was associated with decreased Cyclin D1, as well as increasing levels of P53 and P21. This evidence concerns the gene TP53 and aneurysmal bone cyst.