NF-κB regulates cell survival and death by exerting the transcription of growth factors such as cell cycle-related genes (Cyclin D1, P53, and P21)11 and anti-apoptotic genes (BCL-2, MCL-1, XIAP, IAP-1, IAP-2, BFL-1, BCL-xl, and Survivin),12,13 thus playing a prominent role in the development of ABC-DLBCLs. The gene discussed is BCL2; the disease is aneurysmal bone cyst.