In conclusion, our study elucidates the regulatory mechanism that circ_0055412 regulated EIF4A3/CAPG axis and miR‐330‐3p/NFATC3/Wnt/β‐catenin pathway to promote cisplatin resistance of glioma cells, which might provide the theoretical and practical basis for glioma therapy. The gene discussed is NFATC3; the disease is glioma.