MAP2K1 and melanoma: For example, it promotes the apoptosis of melanoma cells by inhibiting the degradation of the P53 upregulated modulator of apoptosis (PUMA) protein, suppresses melanoma cell invasion and metastasis by normalizing the tumour vasculature, and increases the sensitivity of GNAQ/11‐mutant melanoma to MEK1/2 inhibition.5, 6, 7