Similarly, Fuller et al. [98] showed that compared to LDLR KO, SR-B1/LDLR dKO mice exhibit abnormal lipoprotein profiles, severe coronary atherosclerosis, MI, and decreased survival rate (average lifespan = 9.4 weeks) when fed a modified Western diet containing high cholesterol (1.25%). The gene discussed is SCARB1; the disease is myocardial infarction.