The conditional SR-B1 KO mice, achieved by flanking exon 1 with Cre recombinase loxP sites to produce a hypomorphic allele (hypomSR-B1 KO)[92], exhibit twofold increase in plasma TC concentrations and 2.5-fold increase in atherosclerosis, as compared to the WT [92]. The gene discussed is SCARB1; the disease is atherosclerosis.