SCARB1 and atherosclerosis: Since EC SR-B1 deficiency does not affect the expression of genes that regulate inflammation in the aorta, or leukocyte-EC adhesion in basal or TNF-mediated pro-inflammatory conditions, a decrease in atherogenic lipoprotein profiles and atherosclerosis caused by EC SR-B1 expression suggests that EC SR-B1 might play a role in cholesterol efflux across ECs.