In ApoE KO mice, SR-B1 deletion (SR-B1/ApoE dKO) produces severe hypercholesterolemia (≈1000 mg/dl) with a significant increase in lipoprotein-FC and HDL particles in the size range of LDL and VLDL [94, 95], with defects in morphology and function like those seen in human congenital heart disease. Here, APOE is linked to Hypercholesterolemia.