The expression of EGFL6, which encodes EGFL6 (a member of the EGF-like superfamily that reportedly promotes tumour cell growth by stimulating angiogenesis44,45), was highly upregulated in TRCs, SMC subclusters and MRCs (Fig. 5c, Extended Data Fig. 7b and Supplementary Table 17). Here, EGFL6 is linked to neoplasm.