In the two groups of different expression trend modules, the core genes such as CD160, GATA2, GNLY, IL2RB and TGFBR3 were downregulated in the sepsis group, while genes such as ELANE, IL1R1, TLR5, FCGR1A, MAPK14 and PCSK9 were upregulated. This evidence concerns the gene TLR5 and Sepsis.