We screened the genes Toll-like receptor 5 (TLR5); FCGR1A; elastase, neutrophil expressed (ELANE); granulysin (GNLY); interleukin-2 receptor (IL-2R) β chain (IL2RB) and transforming growth factor beta receptor III (TGFBR3) as being associated with the prognosis of sepsis and identified miRNAs that negatively regulate these key genes. This evidence concerns the gene IL2RB and Sepsis.