We screened the genes Toll-like receptor 5 (TLR5); FCGR1A; elastase, neutrophil expressed (ELANE); granulysin (GNLY); interleukin-2 receptor (IL-2R) β chain (IL2RB) and transforming growth factor beta receptor III (TGFBR3) as being associated with the prognosis of sepsis and identified miRNAs that negatively regulate these key genes. Here, GNLY is linked to Sepsis.