CXCL8 and chronic obstructive pulmonary disease: LAS194046 concentration-dependently (0.01 nM–1 μM) inhibited the mediator secretion induced by LPS (1 μg/ml) similarly in both healthy and COPD neutrophils, showing the maximal % inhibition of 70.54 ± 15% and 58.95 ± 22.64% for IL-8 respectively, and 98.1 ± 14.86% and 97.68 ± 3.29% for MMP9 release (Fig. 1A,B, Supplementary File 1: Table S3).