The maximal % inhibition in neutrophils from severe asthma patients was 45.1 ± 7.5% and 63.44 ± 2.44 for IL-8 and MMP9 release, significantly lower than in neutrophils from healthy and COPD patients (Fig. 1A,B Supplementary File 1: Table S3). This evidence concerns the gene MMP9 and asthma.