In summary, the SNPs panel of one variant/gene (C-kit, SATB1, TP53, MVB12A, ZC3H7A, ZNHIT6, MET, PTEN, HYALP1, MYC, and LMNB1), three variants/gene (FLT3 and SPAM1), four variants/gene (POT1 and HYAL4), five variants/gene (SEL1L), and 11 variants/gene (TRAF3) were determined in dogs with diffuse large B-cell lymphoma. The gene discussed is HYAL4; the disease is diffuse large B-cell lymphoma.