All dog breeds with DLBCL had mutations at SATB1Q420P (c.1259 A > C, Gln420Pro) and HYAL4 (rs8499846, 14:11791385, 14:11794735 and 14:11807161) (Table 2 and Fig. 1). Here, HYAL4 is linked to diffuse large B-cell lymphoma.